This is a collaborative research between Department of Medicinal Chemistry and Department of Microbiology at University of Medicine and Pharmacy at Ho Chi Minh City, of which I am a member. These result published on Ho Chi Minh City Journal of Medicine, Vol. 24 – No. 2 – 2020.
Citation: Nguyen Huu Dai, Ly Nguyen Hai Du, Phan Canh Trinh, Nguyen Duc Tai, Huynh Thi Ngoc Phuong. “Synthesis and evaluation of antibacterial and antifungal activities of some hydrazone derivatives of chalcones.” Ho Chi Minh City Journal of Medicine 24 (2). 2020: 207 – 211.
Fulltext: Read here
Background: Combining two groups of structures of chalcone and hydrazone on the same molecule can create new structures with a better biological effect. In this topic, some hydrazones from chalcone have been synthesized and tested for activity to contribute to diversifying groups of potential antibacterial, antifungal compounds. Objectives: Synthesis and testing of antifungal, antibacterial activity of some hydrazone compounds obtained from chalcone derivatives and semithiocarbazid.
Methods: Synthesis of chalcone derivatives from 5-bromo-2-hydroxybenzaldehyde, salicylaldehyde and some aromatic ethane-1-one derivatives. These chalcones will be reacted with thiosemicarbazide to create the corresponding hydrazones.
Results: The 8 derivatives are synthesized includihng 4 chalcone derivatives and 4 hydrazone derivatives. The activity test results showed that 2 hydrazone derivatives 2 – ((E) -3- (5-bromo-2-hydroxyphenyl) -1- (4-bromophenyl) allylidene) hydrazine carbothioamide [HC5] and 2 – ((E) -3- (5-bromo-2-hydroxyphenyl) -1- (p-tolyl) allylidene) hydrazine carbothioamide [HC6] good antibacterial on Microsporum canis with MIC ≤ 32 µg/mL. These two substances also have good activitives on two strains of tested bacteria, HC5: MSSA-MIC = 0.25 µg/mL; E. coli – MIC = 0.5 µg / mL; HC6: MSSA-MIC = 0.25 µg / mL; E. coli – MIC = 1 µg/mL. HC5 is a new, unpublished substance (SciF. July 17, 2019).
Conclusion: The synthesized hydrazones have a better antibacterial and antifungal effect on test strains than their respective chalcones. This shows the antibacterial potential of hydrazone derivatives from chalcone.
Key words: chalcone, hydrazone, antibacterial hydrazones